Top Ten for 2010

Marijuana leads the list.

Most viewed Addiction Inbox 2010 blog posts, ranked by total pageviews:


1. Marijuana and Memory: Do certain strains make you more forgetful?

“Cannabis snobs have been known to argue endlessly about the quality of the highs produced by their favorite varietals: Northern Lights, Hawaiian Haze, White Widow, etc….”

2.  The Bong Water Case Revisited: Minnesota v. Peck.

“Astute readers will recall the Great Bong Water Decision of 2009, in which the Minnesota Supreme Court determined, 4-3, that water used in a water pipe can be considered a ‘drug mixture’….”

3. Cannabis Receptors and the “Runner’s High”--Maybe it isn't endorphins after all.

“What do long-distance running and marijuana smoking have in common? Quite possibly, more than you’d think. A growing body of research suggests that the runner’s high and the cannabis high are more similar than previously imagined….”

4. More Vanishing Cigarettes: Churchill, Bette Davis, Don Draper, and Pecos Bill.

“In my last post, I highlighted some examples of attacks on cultural history represented by cigarette censorship, to wit: a cigarette taken out of the hand of Paul McCartney, and out of the mouths of Jackson Pollock and Burt Reynolds.…”

5. Cocaine Treatment and the Stroop Test: Treatment dropouts do poorly on color/word match.

“It’s commonly used to demonstrate behavioral inhibition, but it’s also a nifty parlor game. It is called the Stroop Test, and it plays off the fact that people are far better at reading words than they are at intentionally ignoring them….”

6. Liking it Vs. Wanting it: The joylessness of drug addiction.

“Hedonism, the pursuit of pleasure for its own sake, is not really the answer to the riddle of drug addiction. The pursuit of pleasure does not explain why so many addicts insist that they abuse drugs in a never-ending attempt to feel normal….”

7. Mephedrone, the New Drug in Town: Bull market for quasi-legal designer highs.

“Most people in the United States have never heard of it. Very few have ever tried it. But if Europe is any kind of leading indicator for synthetic drugs (and it is), then America will shortly have a chance to get acquainted with mephedrone….”

8. Sex, Drugs, and… Sex: Pharmaceuticals and sexual performance.

“The search for aphrodisiacs is an ancient, if not always venerable, human pursuit. Named for Aphrodite, the Greek goddess of love, aphrodisiacs are compounds that have the reputation, real or imagined, of increasing sexual desire, pleasure, and potency….”

9. Meth Babies—Fact or Fiction? Research team finds brain abnormalities.

“When it came to babies born to crack-addicted mothers, the media went overboard, creating a crisis in the form of an epidemic that never quite was. By contrast, when it came to babies born to alcoholic mothers, Fetal Alcohol Syndrome went unrecognized in the science and medical community until 1968….”

10. Marijuana Use Up, Up, Up: NIDA releases annual survey of teen drug use.

“Research compiled from an annual survey of 8th, 10th and 12th graders by the National Institute on Drug Abuse (NIDA) shows that “marijuana use increased among eighth-graders, and daily marijuana use increased significantly among all three grades….”

Graphics Credit: http://www.thoughttheater.com/

Science Books for Christmas

Women and children first.

It’s not my fault that some of the best science books of 2010 were written by women. In fact, I’m just going to say it: All of the best science books of the year were written by women. Here are a few candidates.

--Rebecca Skloot, The Immortal Life of Henrietta Lacks 

Publishers Weekly: “A tale of medical wonders and medical arrogance, racism, poverty and the bond that grows, sometimes painfully, between two very different women—Skloot and Deborah Lacks—sharing an obsession to learn about Deborah's mother, Henrietta, and her magical, immortal cells.”

--Mary Roach, Packing for Mars: The Curious Science of Life in the Void

Publishers Weekly: “Roach (Stiff) once again proves herself the ideal guide to a parallel universe. Despite all the high-tech science that has resulted in space shuttles and moonwalks, the most crippling hurdles of cosmic travel are our most primordial human qualities: eating, going to the bathroom, having sex and bathing, and not dying in reentry.”

--Mia Szalavitz, Born for Love: Why Empathy is Essential and Endangered 

Product Description: “An inside look at the power of empathy: Born for Love is an unprecedented exploration of how and why the brain learns to bond with others—and a stirring call to protect our children from new threats to their capacity to love.”

--Deborah Blum, The Poisoners Handbook: Murder and the Birth of Forensic Medicine in Jazz Age New York

Publishers Weekly: “Pulitzer Prize–winning science journalist Blum (Ghost Hunters) makes chemistry come alive in her enthralling account of two forensic pioneers in early 20th-century New York. Blum follows the often unglamorous but monumentally important careers of Dr. Charles Norris, Manhattan's first trained chief medical examiner, and Alexander Gettler, its first toxicologist.”

--Jennifer Ouellette, The Calculus Diaries: How math can help you lose weight, win in Vegas, and Survive a Zombie Apocalypse

Nature: "In The Calculus Diaries, science writer Jennifer Ouellette makes maths palatable using a mix of humour, anecdote and enticing facts...Using everyday examples, such as petrol mileage and fairground rides, Ouellette makes even complex ideas such as calculus and probability appealing."

--Susan Casey, The Wave: In Pursuit of the Rogues, Freaks and Giants of the Ocean

Bookmarks Magazine: “Part science lesson and part adrenaline rush, The Wave is an intense thrill ride that manages to take a broad look at oversized, potentially devastating waves. The critics praised Casey's eloquent writing and jaw-droppingly vivid descriptions of chasing--or trying desperately to steer clear of--these aquatic behemoths.”

And:

Smithsonian science books for kids.

Graphics Credit: http://www.zoology.ubc.ca/

Marijuana Use Up, Up, Up

NIDA releases annual survey of teen drug use.

Research compiled from an annual survey of 8th, 10th and 12th graders by the National Institute on Drug Abuse (NIDA) shows that “marijuana use increased among eighth-graders, and daily marijuana use increased significantly among all three grades. The 2010 use rates were 6.1 percent of high school seniors, 3.3 percent of 10th -graders, and 1.2 percent of eighth-graders compared to 2009 rates of 5.2 percent, 2.8 percent, and 1.0 percent, respectively.”

At a news conference held to announce the results of the study, NIDA director Dr. Nora Volkow said that “high rates of marijuana use during the teen and pre-teen years, when the brain continues to develop, place our young people at particular risk. Not only does marijuana affect learning, judgment, and motor skills, but research tells us that about 1 in 6 people who start using it as adolescents become addicted.”

The annual report, called “Monitoring the Future,” takes the temperature of current teen drug use through interviews with more than 50,000 students across the country. The research is conducted at the Survey Research Center in the Institute for Social Research at the University of Michigan.

The survey showed that teen use of Ecstasy is on the increase as well. According to NIDA, “The MTF survey also showed a significant increase in the reported use of MDMA, or Ecstasy, with 2.4 percent of eighth-graders citing past-year use, compared to 1.3 percent in 2009. Similarly, past-year MDMA use among 10th-graders increased from 3.7 percent to 4.7 percent in 2010.”

As for cigarettes, the recent downward trend has “stalled” after several years of steady improvement, said NIDA. “Greater marketing of other forms of tobacco prompted the 2010 survey to add measures for 12th-graders’ use of small cigars (23.1 percent) and of tobacco with a smoking pipe known as a hookah (17.1 percent).”

For the first time, according to the survey, “declines in cigarette use accompanied by recent increases in marijuana use have put marijuana ahead of cigarette smoking by some measures. In 2010, 21.4 percent of high school seniors used marijuana in the past 30 days, while 19.2 percent smoked cigarettes.”

The survey detected a downward trend in binge drinking across the board. Prescription drug abuse remained fairly steady.

The survey also tracks students’ perception of drugs and their risks, and the degree to which drug are viewed as harmful. The report concludes: “Related to its increased use, the perception that regular marijuana smoking is harmful decreased for 10th- graders (down from 59.5 percent in 2009 to 57.2 percent in 2010) and 12th-graders (from 52.4 percent in 2009 to 46.8 percent in 2010). Moreover, disapproval of smoking marijuana decreased significantly among eighth-graders.”

The survey at the University of Michigan is led by Dr. Lloyd Johnston, operating under a NIDA grant. Additional information on the MTF Survey, as well as comments from Dr. Volkow can be found at http://www.drugabuse.gov/drugpages/MTF.html.

Era of the Electronic Cigarette Officially Begins.

Court blocks FDA from prohibiting e-cigarettes.

It’s official: The e-cigarette is here. The right of a distributor of Chinese electronic cigarettes to market the product in the U.S. was solidly affirmed last week by a three-judge ruling in the U.S. Court of Appeals for the District of Columbia. The Food and Drug Administration’s refusal last year to allow importation of e-cigarettes by Sottera Inc. had been the basis for a lower court decision in Sottera’s favor. The earlier court ruled that e-cigarettes did not require FDA approval because they were neither new drugs nor new drug delivery devices. (The FDA is prohibited by an act of Congress from barring the sale of tobacco products outright.)

Last month, under a consent judgement worked out with California state Attorney General Jerry Brown in a related case, Florida-based Smoking Everywhere Co., another distributor of Chinese electronic cigarettes, had agreed not to target minors in its advertising, or to make claims that its products are safe alternatives to tobacco. The move came shortly after the FDA announced plans to regulated battery-powered e-cigarettes as new drug delivery devices, culminating in the Sottera lawsuit.

The legal argument before the appeals court hinged largely on semantics. The court found that electronic cigarettes are “battery-powered products that allow users to inhale nicotine vapor without fire, smoke, ash or carbon monoxide. The liquid nicotine is derived from natural tobacco plants.”

Here is the catch: “The FDA may only approve a product for marketing under the Federal Food, Drug and Cosmetic Act (FDCA) if it is safe and effective for its intended use,” the Appeals Court Justices ruled.  However, the FDA has “exhaustively documented” that tobacco products are unsafe for pharmacological use of any kind. The earlier court had concluded, stealing a page from “Alice in Wonderland”: “If they cannot be used safely for any therapeutic purpose, and yet they cannot be banned, they simply do not fit” within any conceivable regulatory scheme.

Hence the difficulties in the FDA’s attempt to regulate by agency fiat. E-cigarette manufacturers and distributors, having sensed an opening, are now ready to drive a convoy of semis right through it. This wasn’t a completely straightforward march, as the e-cigarette forces, in the appeals presentation, were required to thread the needle on such conundrums as: Does it matter that e-cigarettes do not, strictly speaking, contain “tobacco products?” Nicotine is a component of, not a product of, tobacco.

You see the problem. The relevant statutes have not been written with pure nicotine delivery devices in mind. In fact, having nicotine--but not the evil substance tobacco--in your product turned out to be a definitional advantage for the e-cigarette marketers: The court pointed out that, unlike products containing tobacco, which the FDA has found to be associated with “cancer, respiratory illnesses, and heart disease,” the FDA has manifestly NOT found that nicotine or tobacco-free products that deliver nicotine are inherently unsafe. And second, the “tobacco-specific legislation” invoked in earlier court cases “simply does not address products that deliver nicotine but contain no tobacco.”

Matthew Myers, president of the Campaign for Tobacco-Free Kids, said in a prepared statement: "This decision will allow any manufacturer to put any level of nicotine in any product and sell it to anybody, including children, with no government regulation or oversight at the present time. We urge the government to appeal this ruling."

Among the many  questions the ruling leaves open is the status of e-cigarettes under existing no-smoking regulations. That litigation has not even gotten underway.

See my earlier post on the e-cigarette question HERE.

For the full court decision, click HERE.

Graphics Credit:  http://thestrobel3.blogspot.com/

Cannabis and Severe Vomiting

Pot can make you puke.

For those of you who missed this, as I did, here is a belated account of a rare but altogether curious side effect of heavy marijuana use: cyclical vomiting.

Nice, eh? And yes, it goes completely against the grain of what we think we know about marijuana: Ironically, cannabis is frequently employed to prevent the nausea and vomiting frequently associated with chemotherapy.

So what gives? The answer is that, so far, nobody really knows.

First things first: It appears to be a very rare side effect of regular marijuana use, and it was not documented in the medical literature until 2004. Given the long history of pot-smoking the world over, it is reasonable to ask where the cannabis emesis syndrome has been hiding all these years.  A fair question, but one which, at this stage, has no satisfying answer.

Cannabinoid hyperemesis, as it's known, was first brought to wider attention earlier this year by the anonymous biomedical researcher who calls himself Drugmonkey. Posting on his eponymous blog, Drugmonkey documented cases of hyperemesis that had been reported in Australia and New Zealand, as well as Omaha and Boston in the U.S.

"There were two striking similarities across all these cases," Drugmonkey reported. "The first is that patients had discovered on their own that taking a hot bath or shower alleviated their symptoms. So afflicted individuals were taking multiple hot showers or baths per day to obtain symptom relief. The second similarity is, as you will have guessed, they were all cannabis users."

Heavy, regular cannabis users, most of them. And hot baths? Where did THAT come from?

More evidence was not long in coming. In February, researchers in the Division of Gastroenterology at William Beaumont Hospital in Royal Oak, Michigan, identified eight patients in their gastroenterology wards who were suffering from "otherwise unexplained refractory, recurrent vomiting." As the researchers reported in the journal Digestive Diseases and Sciences, there were two other significant features the eight patients shared: They were all chronic cannabis smokers--and they were all compulsive bathers.

The connection between uncontrolled vomiting and heavy toking seemed unequivocal: "Four out of five patients who discontinued cannabis use recovered from the syndrome," according to the published report, "while the other three patients who continued cannabis use, despite recommendations for cessation, continued to have this syndrome."

There is precious little anecdotal evidence to support this surprising finding. Occasionally, naive marijuana smokers will ingest too much and become sick to their stomach. And it is possible to incur the (brief) wrath of cyclic vomiting by eating way too many marijuana brownies, or other cannabis foodstuffs. Short of that, I am not familiar with vomiting as a documented side effect of regular cannabis use, and I venture to guess that most readers aren't, either.

However, the reports haven't stopped. This summer, an intriguing account appeared in Clinical Correlations, the official blog of New York University's Division of General Internal Medicine. Sarah A. Buckley and Nicholas M. Mark, 4th year medical students at the NYU School of Medicine, speculated on the cannabis hyperemesis phenomenon, and offered a formal definition: "A clinical syndrome characterized by intractable vomiting and abdominal pain associated with the unusual learned behavior of compulsive hot water bathing, occurring in the setting of long-term heavy marijuana use."

After reviewing 16 published papers on the syndrome, Buckley and Mark asked the obvious question: "How can marijuana, which is used in cancer clinics as an anti-emetic, cause intractable vomiting? And why would symptoms abate in response to high temperature?"

One possible mechanism involves marijuana's penchant for fats. Theoretically, this "lipophilicity" could cause increasingly toxic concentrations of THC over time, in susceptible people. "The abdominal pain and vomiting are explained by the effect of cannabinoids on CB-1 receptors in the intestinal nerve plexus," they write, "causing relaxation of the lower esophageal sphincter and inhibition of gastrointestinal motility." The authors speculate that low doses of THC might be anti-emetic, whereas in certain people, the high concentrations produced by long-term use could have the opposite effect.

As for the hot baths, Buckley and Mark note that "cannabis disrupts autonomic and thermoregulatory functions of the hippocampal-hypothalamic-pituitary system," which is loaded with CB-1 receptors. The researchers conclude, however, that the link between marijuana and thermoregulation "does not provide a causal relationship" for what they refer to as "this bizarre learned behavior."

These questions, like many questions having to do with regular marijuana use, are not likely to be answered definitively anytime soon, for a number of good reasons, some of which are delineated by the authors:

--"The legal status of marijuana makes eliciting an accurate drug history challenging."

--"The bizarre hot water bathing is likely often attributed to psychological conditions such as obsessive-compulsive behavior."

--"The knowledge of the anti-emetic effects of cannabis likely disguise cases of cannabinoid hyperemesis, leading to the erroneous belief that cannabis is treating cyclic vomiting rather than causing it."

--"The fact that this syndrome is so recently described and relatively unknown outside an esoteric subset of the GI [gastrointestinal] literature means that most clinicians are unaware of its existence."

Graphics Credit: http://www.oxygentimerelease.com/

MAPS Sponsors Psychedelic Confab

And J.R. will discuss his LSD trips with you.

The Multidisciplinary Association of Psychedelic Studies (MAPS) has put together a roster of very big psychedelic guns, as well as a few surprises, for its mini-conference on December 12-13 in Los Angeles. On tap for the convocation are such luminaries as Stanislav Grof of Holotropic Breathwork fame; as well as Charles Grob, professor of Psychiatry and Pediatrics at the UCLA School of Medicine and a psychedelic research of long standing who recently studied the effects of psilocybin on death anxiety in terminal cancer patients.

“Catalysts: The Impact of Psychedelics from Consciousness to the Clinic, and from Culture to Creativity” will feature presentations and discussions on “psychedelic science, the current state of psychedelic research, and clinical applications for therapeutic use.”

Other experts among the scientists, physicians, psychologists, writers, and artists expected to attend include Rick Doblin, the founder of MAPS, who has specialized in research on MDMA (Ecstasy) as a treatment for posttraumatic stress disorder. Another scheduled attendee, James Fadiman, was introduced to the field of psychedelic drugs by his Harvard undergraduate advisor Richard Alpert, who later became well known as Baba Ram Dass. Fadiman holds the distinction of being the last LSD researcher to be shut down by the U.S. government, when he was at San Francisco State University in 1972.

Also in attendance will be Julie Holland, an assistant professor of psychiatry at NYU School of Medicine, and the author of “Ecstasy: A Complete Guide,” and Clare Wilkins, director of the Pangea Biomedics Ibogaine Clinic in Mexico.

Special Bonus Appearance:

I can’t imagine that anyone under the age of 55 is likely to know who Larry Hagman is. Long ago, he was on a camp TV show about a Texas oil bazillionaire with nasty habits. Not only was he a big TV star, he was also old enough to have been around when LSD psychotherapy came to the couches of Hollywood analysts for a brief period in the 1960s and attracted some other odd ducks like Cary Grant and James Coburn. Hagman, Star of TV’s “Dallas” and “I Dream of Jeannie,” will discuss his experiences with LSD psychotherapy.

Earlier, he talked about his experiences in a 2003 interview with Rick Doblin, published in the MAPS journal and excerpted below:

Before I tried LSD, I'd been going to a psychologist for a couple of years…. I had been addicted to tobacco and Bontril, a mild form of amphetamine, doctor-prescribed of course….

I was backstage at a performance one time with Crosby, Stills & Nash and I was talking about it to David Crosby. David said, well, shit, man, here. He handed me a handful of little pills. I said what the fuck? He says this is LSD. It was the best going around at that time. This was before Blue Cheer and Windowpane. This was the original Owsley. He gave me about 25 pills. I said, well, how much should I take? He says, well, don't take more than one….

… my first acid trip was the most illuminating experience of my life. I would highly recommend it for people who study and prepare for it and who are not neurotic or psychotic. I don't know what it would do to psychotic people. I know what it does to neurotic people who can't handle that. They get terrified and do crazy things like jumping out of windows and stuff like that. That's happened to a couple of friends of mine.

Graphics Credit: http://en.wikipedia.org/wiki/Larry_Hagman

World AIDS Day

Testing, Testing.

Guest Post By Kevin Fenton, M.D., Ph.D., FFPH, Director, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention (CDC). 

Every year on December 1, we commemorate World AIDS Day to bring attention to the tremendous impact of the HIV epidemic in the United States and around the world. In observance of World AIDS Day, today CDC launched a special report, CDC Vital Signs on HIV Testing in the United States, in recognition of the pivotal role that HIV testing plays in our national HIV prevention strategy.

Some highlights of the CDC Vital Signs report on HIV testing include:

    •    In 2009, an estimated 82.9 million Americans ages 18-64—45% of this age group—reported they had been tested for HIV.

    •    At least 1 in 3 Americans who test positive for HIV is tested too late in his or her infection to get the full advantage of life-saving treatment.

    •    Gay, bisexual, or other men who have sex with men have the highest rates of HIV, but a 2008 study conducted in 21 major US cities, found that about 40% had not been tested in the past year.

    •   African Americans made up more than half of HIV diagnoses in 2008, but 2 in 5 African Americans have never been tested.

CDC recommended in 2006 that HIV testing become a routine part of medical care, including testing of all adolescents and adults at least once, testing at least annually for persons at increased risk, and testing of women during each pregnancy. Since that time, HIV testing has increased, and more people are being tested for HIV than ever before. However, many challenges remain: 55% of Americans ages 18 to 64 still have never been tested, according to CDC Vital Signs. And of the estimated 1.1 million people living with HIV in the United States, 1 in 5 do not know they are infected.

More needs to be done. HIV testing is vitally important because it can save lives. For anyone who is infected, it is important to know his or her HIV status in order to access effective life-extending treatment, avoid HIV transmission to partners, and have a better quality of life.

Treatment for HIV is most effective before symptoms develop. It can do much to slow the infection that leads to AIDS and death. Without treatment a person infected with HIV will develop AIDS in about 10 years. With early treatment a 25-year-old adult can survive on average 39 more years.

According to the Vital Signs report, nearly one-third (32%) of the people found with HIV in 2007 were diagnosed late. This means that they likely had HIV for a long time without knowing it because they developed AIDS soon (less than one year) after their HIV test.

Health care providers play a critical role in stopping the spread of HIV as most HIV testing is conducted in health care settings. It is important that patients listen to their doctors and it is important that doctors and other health care providers speak openly and honestly with patients about HIV, and offer routine testing per CDC recommendations.

CDC also plays a critical role. We are committed to strengthening our efforts against the epidemic and working with partners to increase HIV testing. CDC continues to expand its efforts in areas where the burden of disease is greatest. We recently announced an expansion of a successful HIV testing initiative to reach more hard-hit populations, including African Americans, Latinos, men who have sex with men and injection drug users. In 2010, CDC provided more than $60 million to support HIV testing efforts in 30 of the hardest hit jurisdictions in the United States.

In addition, CDC provides funds to all health departments and more than 130 community-based organizations to implement HIV prevention programs, including HIV testing. We are also working to get messages out about testing through the Act Against AIDS  campaign. Of critical importance, the National HIV/AIDS Strategy, recently released by the White House, provides a new opportunity to refocus and intensify federal, state, and local HIV testing efforts.

Now more than ever, effective HIV prevention is a critical public health priority for the U.S. and the world, and HIV testing to identify those infected is a vital component of that effort. Working together, we can increase HIV testing. Everyone needs to know how important HIV testing is – it is a simple measure that can literally save the health and lives of hundreds of thousands of Americans and help to bring an end to this tragic epidemic.