tag:blogger.com,1999:blog-142743152971096915.post7619294584429283649..comments2023-10-05T04:44:25.174-05:00Comments on Addiction Inbox: Consider the CB(2) ReceptorDirk Hansonhttp://www.blogger.com/profile/07429793255785560043noreply@blogger.comBlogger4125tag:blogger.com,1999:blog-142743152971096915.post-64730247944906124312010-07-18T18:46:15.711-05:002010-07-18T18:46:15.711-05:00Thanks for the info, Neuroskeptic. We're only ...Thanks for the info, Neuroskeptic. We're only just beginning to take apart cannabis and see what makes it tick, in a sense. I calculate that the scientific community lost as much as three decades of research time, relative to other drugs of abuse, due to the Feds putting pot research on hold.Dirk Hansonhttps://www.blogger.com/profile/07429793255785560043noreply@blogger.comtag:blogger.com,1999:blog-142743152971096915.post-76582660847009151072010-07-18T04:14:26.427-05:002010-07-18T04:14:26.427-05:00THC, the active ingredient in cannabis, is a combi...THC, the active ingredient in cannabis, is a combined CB1 and CB2 agonist. We don't really know what proportion of the effects of cannabis are related to CB2 agonism, probably not many given that selective CB1 agonists have similar subjective effects, but CB2 may play a part. If they're in the brain, they must do something...Neuroskeptichttps://www.blogger.com/profile/06647064768789308157noreply@blogger.comtag:blogger.com,1999:blog-142743152971096915.post-4511027875034878222010-07-09T09:50:38.163-05:002010-07-09T09:50:38.163-05:00I don't know the answer to that. And I'm n...I don't know the answer to that. And I'm not entirely convinced about the cannabis psychosis question. Correlation is not causation. People with existing mental problems, or incipient mental illness like schizophrenia, often turn to drugs.Dirk Hansonhttps://www.blogger.com/profile/07429793255785560043noreply@blogger.comtag:blogger.com,1999:blog-142743152971096915.post-73730012190533243162010-07-09T02:16:25.824-05:002010-07-09T02:16:25.824-05:00Casual observer here: Is it possible that CB2 acti...Casual observer here: Is it possible that CB2 activation might still lead to the dreaded cannabis psychosis while not getting you high, or do you consider that an impossibility?Larsnoreply@blogger.com